tipmap: Tipping Point Analysis for Bayesian Dynamic Borrowing

Tipping point analysis for clinical trials that employ Bayesian dynamic borrowing via robust meta-analytic predictive (MAP) priors. Mainly an implementation of an approach proposed by Best and colleagues (2021) is provided <doi:10.1002/pst.2093>. Further functions facilitate the specification of the robust MAP prior via expert elicitation (using the roulette method) and computation of the posterior distribution of the treatment effect with either fixed or stochastic expert-elicited weights. Intended use is the planning, analysis and interpretation of extrapolation studies in pediatric drug development, but applicability is generally wider.

Version: 0.4.1
Depends: R (≥ 3.5.0)
Imports: dplyr, purrr, ggplot2, RBesT
Suggests: knitr, rmarkdown, tidyr, magrittr, tibble, testthat (≥ 3.0.0)
Published: 2023-04-24
Author: Morten Dreher [aut], Christian Stock ORCID iD [aut, cre], Emma Torrini [ctb]
Maintainer: Christian Stock <christian.stock at boehringer-ingelheim.com>
BugReports: https://github.com/chstock/tipmap/issues
License: Apache License 2.0
URL: https://github.com/chstock/tipmap
NeedsCompilation: no
Materials: README NEWS
CRAN checks: tipmap results


Reference manual: tipmap.pdf
Vignettes: Determining a weight of the informative prior component
Introduction to the 'tipmap' package


Package source: tipmap_0.4.1.tar.gz
Windows binaries: r-devel: tipmap_0.4.1.zip, r-release: tipmap_0.4.1.zip, r-oldrel: tipmap_0.4.1.zip
macOS binaries: r-release (arm64): tipmap_0.4.1.tgz, r-oldrel (arm64): tipmap_0.4.1.tgz, r-release (x86_64): tipmap_0.4.1.tgz, r-oldrel (x86_64): tipmap_0.4.1.tgz
Old sources: tipmap archive


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