refineR: Reference Interval Estimation using Real-World Data

Indirect method for the estimation of reference intervals using Real-World Data ('RWD'). It takes routine measurements of diagnostic tests, containing pathological and non-pathological samples as input and uses sophisticated statistical methods to derive a model describing the distribution of the non-pathological samples. This distribution can then be used to derive reference intervals. Furthermore, the package offers functions for printing and plotting the results of the algorithm. See ?refineR for a more comprehensive description of the features. Version 1.0 of the algorithm is described in detail in 'Ammer et al. (2021)' <doi:10.1038/s41598-021-95301-2>. Additional guidance on the usage of the algorithm is given in 'Ammer et al. (2023)' <doi:10.1093/jalm/jfac101>.

Version: 1.6.1
Depends: R (≥ 3.2.0)
Imports: stats, ash, future, future.apply, parallel, graphics, grDevices
Suggests: knitr, rmarkdown
Published: 2023-11-14
DOI: 10.32614/CRAN.package.refineR
Author: Tatjana Ammer [aut, cre], Christopher M Rank [aut], Andre Schuetzenmeister [aut]
Maintainer: Tatjana Ammer <tatjana.ammer at>
License: GPL (≥ 3)
NeedsCompilation: no
Materials: NEWS
CRAN checks: refineR results


Reference manual: refineR.pdf
Vignettes: refineR: Reference Interval Estimation using Real-World Data (RWD)


Package source: refineR_1.6.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): refineR_1.6.1.tgz, r-oldrel (arm64): refineR_1.6.1.tgz, r-release (x86_64): refineR_1.6.1.tgz, r-oldrel (x86_64): refineR_1.6.1.tgz
Old sources: refineR archive


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