grouprar: Group Response Adaptive Randomization for Clinical Trials

Implement group response-adaptive randomization procedures, which also integrates standard non-group response-adaptive randomization methods as specialized instances. It is also uniquely capable of managing complex scenarios, including those with delayed and missing responses, thereby expanding its utility in real-world applications. This package offers 16 functions for simulating a variety of response adaptive randomization procedures. These functions are essential for guiding the selection of statistical methods in clinical trials, providing a flexible and effective approach to trial design. Some of the detailed methodologies and algorithms used in this package, please refer to the following references: LJ Wei (1979) <doi:10.1214/aos/1176344614> L. J. WEI and S. DURHAM (1978) <doi:10.1080/01621459.1978.10480109> Durham, S. D., FlournoY, N. AND LI, W. (1998) <doi:10.2307/3315771> Ivanova, A., Rosenberger, W. F., Durham, S. D. and Flournoy, N. (2000) <> Bai Z D, Hu F, Shen L. (2002) <doi:10.1006/jmva.2001.1987> Ivanova, A. (2003) <doi:10.1007/s001840200220> Hu, F., & Zhang, L. X. (2004) <doi:10.1214/aos/1079120137> Hu, F., & Rosenberger, W. F. (2006, ISBN:978-0-471-65396-7). Zhang, L. X., Chan, W. S., Cheung, S. H., & Hu, F. (2007) <> Zhang, L., & Rosenberger, W. F. (2006) <doi:10.1111/j.1541-0420.2005.00496.x> Hu, F., Zhang, L. X., Cheung, S. H., & Chan, W. S. (2008) <doi:10.1002/cjs.5550360404>.

Version: 0.1.0
Depends: R (≥ 3.6.0)
Imports: ggplot2 (≥ 3.3.0), gridExtra (≥ 2.3), stringr (≥ 1.4.0), methods, extraDistr, tidyr, stats
Published: 2024-03-04
DOI: 10.32614/CRAN.package.grouprar
Author: Guannan Zhai [aut, cre], Feifang Hu [aut, ths]
Maintainer: Guannan Zhai <guannanzhai1996 at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: yes
CRAN checks: grouprar results


Reference manual: grouprar.pdf


Package source: grouprar_0.1.0.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): grouprar_0.1.0.tgz, r-oldrel (arm64): grouprar_0.1.0.tgz, r-release (x86_64): grouprar_0.1.0.tgz, r-oldrel (x86_64): grouprar_0.1.0.tgz


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