Frequentist sequential meta-analysis based on 'Trial Sequential Analysis' (TSA) in programmed in Java by the Copenhagen Trial Unit (CTU). The primary function is the calculation of group sequential designs for meta-analysis to be used for planning and analysis of both prospective and retrospective sequential meta-analyses to preserve type-I-error control under sequential testing. 'RTSA' includes tools for sample size and trial size calculation for meta-analysis and core meta-analyses methods such as fixed-effect and random-effects models and forest plots. TSA is described in Wetterslev et. al (2008) <doi:10.1016/j.jclinepi.2007.03.013>. The methods for deriving the group sequential designs are based on Jennison and Turnbull (1999, ISBN:9780849303166).
|Depends:||R (≥ 3.5.0)|
|Imports:||stats, metafor, ggplot2, scales, Rcpp (≥ 0.11.0)|
|Suggests:||gsDesign, CompQuadForm, dplyr, kableExtra, rmarkdown, knitr, bookdown, gridExtra, testthat (≥ 3.0.0)|
|Author:||Anne Lyngholm Soerensen [aut, cre, trl], Markus Harboe Olsen [aut, ctr], Theis Lange [ctr], Christian Gluud [ctr]|
|Maintainer:||Anne Lyngholm Soerensen <lynganne at gmail.com>|
|License:||GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]|
|CRAN checks:||RTSA results|
RTSA - Standard operational protocol
Futility boundaries in RTSA
Prospective and retrospective sequential meta-analysis
Calculating required sample size and required number of trials
|Windows binaries:||r-devel: RTSA_0.2.2.zip, r-release: RTSA_0.2.2.zip, r-oldrel: RTSA_0.2.2.zip|
|macOS binaries:||r-release (arm64): RTSA_0.2.2.tgz, r-oldrel (arm64): RTSA_0.2.2.tgz, r-release (x86_64): RTSA_0.2.2.tgz, r-oldrel (x86_64): RTSA_0.2.1.tgz|
|Old sources:||RTSA archive|
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