AllelicSeries: Allelic Series Test

Implementation of gene-level rare variant association tests targeting allelic series: genes where increasingly deleterious mutations have increasingly large phenotypic effects. The COding-variant Allelic Series Test (COAST) operates on the benign missense variants (BMVs), deleterious missense variants (DMVs), and protein truncating variants (PTVs) within a gene. COAST uses a set of adjustable weights that tailor the test towards rejecting the null hypothesis for genes where the average magnitude of effect increases monotonically from BMVs to DMVs to PTVs. See McCaw ZR, Somineni H, Bereket M, Klein C, Karaletsos T, Casale FP, Koller D, Soare TW. (2022) "An allelic series rare variant association test for candidate gene discovery" <doi:10.1101/2022.12.23.521658>.

Imports: Rcpp, RNOmni, SKAT
LinkingTo: Rcpp, RcppArmadillo
Suggests: knitr, rmarkdown, testthat (≥ 3.0.0), withr
Published: 2023-01-13
Author: Zachary McCaw ORCID iD [aut, cre], Christoph Klein ORCID iD [ctb], insitro [cph]
Maintainer: Zachary McCaw <zmccaw at>
License: BSD_3_clause + file LICENSE
NeedsCompilation: yes
CRAN checks: AllelicSeries results


Reference manual: AllelicSeries.pdf
Vignettes: my-vignette


Package source: AllelicSeries_0.0.2.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): AllelicSeries_0.0.2.2.tgz, r-oldrel (arm64): AllelicSeries_0.0.2.2.tgz, r-release (x86_64): AllelicSeries_0.0.2.2.tgz, r-oldrel (x86_64): AllelicSeries_0.0.2.2.tgz


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